The death of one of Australia’s great medical scientists, Emeritus Professor Frank Fenner, has, not surprisingly, made international headlines.

In 2007, I had the pleasure of interviewing Fenner for a profile commissioned by a pathology magazine, PathWay (you can read more from this at the bottom of the post).

At that time, he had begun the task of packing up his office in the John Curtin School of Medical Research in Canberra – almost 30 years after his official retirement. I wrote in the profile that: “Professor Fenner is widely admired, not only because of the longevity of his career and the breadth of his achievements, but also because of his humility and decency.”

Below are some of the comments that have arrived from his colleagues and friends since the news broke yesterday of his death, at age 95.

Professor Tony McMichael
National Centre for Epidemiology & Population Health, ANU College of Medicine, Biology and Environment
The Australian National University

The thing I best knew about Frank, and discussed with him, was his deep understanding of (and concern for) the future of the biosphere, under mounting human pressures and traumas.  He had a profound insight into ecological systems and the limits to their capacity to maintain vitality, and to produce, regenerate and absorb.  He foresaw a likely crisis for human populations, their wellbeing, health and survival, unless we shifted collectively and radically to a sustainable way of living on this planet. He was, in this, a great supporter of Stephen Boyden’s ideas about the need for a ‘biosensitive’ society — and he was a longtime supporter and substantial (though discreet) benefactor of the Canberra-based Nature and Society Forum (established by Boyden two decades, to pursue thes ideas and goals).

About three decades ago, Frank gave a talk at a conference in which he posed a question along these lines: If the sabre tooth tiger went extinct because of its ultimately over-sized sabre teeth, which became dysfunctional in a changing environment, might we humans not be at similar risk from the consequences of our outsized and often-too-clever brains — and the mismatch of much of their product with the limited capacity of the natural environment.

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Dr Tom Gottlieb
Senior Specialist in Microbiology and Infectious Diseases
Department of Microbiology and Infectious Diseases
Concord Hospital

Frank was the first (and to date only) patron of ASID – the Australasian Society for Infectious Diseases.

It was a tribute to the great reverence by which he was held by all the members of the society.

Until the past few years he would always make an effort to come to the meetings. The last time he spoke, I think it was 3 years ago, he held the meeting in thrall with recollections especially in relation to eradication of smallpox.

Sitting with Frank was not only a brush with fame and medical history (in an infectious diseases sense), it was a delight. He was very generous with his time and was very supportive of the society, and he will be greatly missed by those of us that had the pleasure of having shared his company.

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Dr Graham Mitchell

Foursight

There are very few people that, based on their achievements on behalf of others and their extraordinarily generous and gentle personality, can claim to be “great”.

Of course, Frank would never claim such but in the view of a large number of people (and certainly me) he was truly that—- a great researcher/virologist, environmentalist/conservationist, Australian/global citizen and teacher/colleague.

Thank you for many lasting memories over all those years Frank.

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Professor Tony Capon
National Centre for Epidemiology and Population Health
ANU

A sage.  An inspiration.  A rascal.  Thank you for the time.

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Earlier this year, Croakey cited an interview with Fenner, conducted by  science journalist Cheryl Jones for an article in  The Australian’s Higher Education supplement.

As Jones noted, Fenner was an authority on extinction. He helped to send one species into oblivion: the variola virus that causes smallpox, and his work on the myxoma virus suppressed wild rabbit populations on farming land in southeastern Australia in the early 1950s.

He told Jones: “We’ll undergo the same fate as the people on Easter Island. Climate change is just at the very beginning. But we’re seeing remarkable changes in the weather already….The human species is likely to go the same way as many of the species that we’ve seen disappear. Homo sapiens will become extinct, perhaps within 100 years. A lot of other animals will, too. It’s an irreversible situation. I think it’s too late. I try not to express that because people are trying to do something, but they keep putting it off. Mitigation would slow things down a bit, but there are too many people here already.”

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Meanwhile, here is the 2007 profile: Scientific luminary prepares to shut up shop

By Melissa Sweet

After a stellar career spanning seven decades, Professor Frank Fenner has begun the difficult task of packing up his office – almost 30 years after his official retirement.

When Professor Fenner finally vacates his room at the John Curtin School of Medical Research in Canberra, as he intends to later this year, it will be the end of an era for Australian science and one of its most revered figures.

“I really have to go home and get things in order,” Professor Fenner explains. After all, he will be 93 in December and doesn’t expect to be able to continue his current routine – rising at 5am, reading the latest journals until 8am and then driving to the Australian National University – for too much longer.

Professor Fenner is widely admired, not only because of the longevity of his career and the breadth of his achievements, but also because of his humility and decency. His name may be up in lights on the main avenue as you drive into Canberra – just outside Fenner Hall, in fact – but none of the usual marks of the celebrity are apparent when you meet the man himself.

When I buzz the security phone to gain entrance to his office building one chilly Canberra morning, his response is typically low key, without a hint of any airs or graces. Just a quiet and simple: “Fenner”.

If you didn’t know his pedigree, you would swear that the blue-eyed, white-haired gent shuffling down the corridor could be anyone’s grandfather. What gives him away is the affection and respect that is so evident in the greetings from colleagues.

When awarded an honorary fellowship of the Royal College of Pathologists of Australasia earlier this year, the citation noted that the award recognised not only Professor Fenner’s scientific and medical contributions, but also the tenacity and humble nature of the man behind the work.

When Professor Fenner arrived at the newly established John Curtin School of Medical Research in 1949, aged 34, he already had quite a reputation.

His work in controlling malaria among World War Two troops had earnt him the recognition of a Member of the Order of the British Empire. A Captain and then a Major in the Australian Army Medical Corps between 1940 and 1946, he developed an interest in infectious diseases during service in Australia, Palestine, Egypt, New Guinea and Borneo.

After the war, he worked alongside Sir Macfarlane Burnet at the Walter and Eliza Hall Institute for Medical Research in Melbourne, where he studied mousepox, a close relative of the smallpox virus. It was the beginning of a lifelong interest in pox viruses.

Much of his first 15 years at the ANU were absorbed by research into another pox virus – myxomatosis. This work, which contributed to the control of the rabbit plague that then decimated the countryside, is widely judged as one of his key  achievements.

However, it was a single unorthodox experiment in 1951 which really caught the general public’s attention. In an effort to reassure those anxious about the safety of releasing myxomatosis, Professor Fenner and two other scientists injected themselves with the virus. All they suffered was a slight reddening at the injection site.

Professor Fenner’s work on myxomatosis also led him into the study of the vaccinia virus, which was to prove such a useful background for the work on smallpox which later brought such international acclaim.

After becoming director of the John Curtin School in 1967, Professor Fenner made a conscious decision to cease scientific research because he didn’t want to do it through assistants or students – “I am temperamentally unable to do research without being personally involved, hands-on at the bench”, he once told a radio interviewer. Instead, he concentrated on writing and other work.

Serendipitously, this allowed him to answer the critical call of his career – to assist the World Health Organization with ridding the world of smallpox transmission, a task requiring a grinding schedule of constant travel.

In a career noted for many awards and prizes, Professor Fenner says his proudest moment came on 8 May, 1980, when he stood before the World Health Assembly in Geneva, as chair of the Global Commission for the Certification of Smallpox Eradication, and declared its mission accomplished.

“Everybody was delighted about it,” he recalls. “That was the great moment.”

In latter decades, Professor Fenner’s focus turned to environmental issues, inspired by one of his great mentors, René Jules Dubos, an American scientist and environmentalist credited with coining the maxim “think globally, act locally”.

Professor Fenner is known among colleagues as a cautious scientist but he has no hesitation in sharing his alarm about global warming and the failure of the United States and Australian Governments to respond appropriately.

“You couldn’t but be very concerned,” he says. “Everybody that lectures on climate change has to end up on a hopeful note, so I try to avoid giving lectures on it because I find it very gloomy.

“You can only think what the world would be like if Al Gore had become president instead of Bush. Obviously we wouldn’t have gone into Iraq and, rather than ignoring climate change, he would have been pushing America to get stuck into it.”

Professor Fenner is similarly upfront about sharing his political convictions. He has never voted for the conservative parties, he says, preferring to support the “underdog”.

“Conservative governments – although I think Menzies did a good job as PM for a long time – they tend to be greatly influenced by other rich men, company owners and so on and so forth,” he says

Nor has Professor Fenner been reticent about digging into his pockets to support the causes close to his heart. After winning the prestigious Japan Prize in 1988 – sharing the ¥500 million bounty with two others involved in smallpox eradication – he established two endowment foundations, to help fund conferences on the environment and medical research.

Writing is another passion. He has published more than 300 scientific papers and written or contributed to 14 books, including a best selling textbook, Medical Virology.

He refers often to the role of both chance and his father in his successes, so it is no surprise that both feature in the title of one of his most personally revealing books, Nature, Nurture and Chance, The Lives of Frank and Charles Fenner. It examines the similarities and differences between the lives and opportunities of the father and son.

When the young Frank, an enthusiastic collector of fossils, was contemplating a career as a geologist, his father suggested medicine would offer more opportunities. Charles Fenner, a teacher who became a senior education administrator in SA, was also a keen scientist and writer. And clearly an influential role model for his son.

Another central figure in Professor Fenner’s life and work was his wife Bobbie, a nurse. They met at work and married in 1943. Much of the first two years of their marriage were spent apart while Fenner was posted to New Guinea.

He wrote to her at least once a day during their separation and was moved, many decades later, to discover she had kept all these notes, which he once described as “pretty torrid love letters”. He found her reading them as she lay sick with inoperable cancer.

Professor Fenner has many times paid public tribute to his wife, both for her support of his career, and for her community work, which was recognised with an Order of the Medal of Australia.

He was devastated by her death in 1995, and has talked of the bleak years which followed. But he picked himself up, helped by the friendships cemented over many decades at regular tennis matches – he gave the game away only last year because of an injury.

Professor Jane Dahlstrom, Professor of Anatomical Pathology at the ANU, recalls that she first came to know Professor Fenner because he was part of a group of scientists who regularly played tennis next door to her home.

As she grew to know him more, bumping into him at various functions and meetings, she came to appreciate him, both as a person and a scientist, and resolved to surprise him by nominating him as a Fellow of the College.

“He genuinely seemed really pleased,” she says. “The day after the function he wrote me a lovely email, thanking me.”

For Dr Peter McCullagh, a developmental immunologist who retired from the John Curtin School in 1991, three things stand out about the man who has been a colleague and friend for more than 40 years. These are his enormous work ethic, his remarkable knowledge of virology, and his example of healthy, active ageing.

“Frank is an incredible example of what one can do, post-65, by staying active,” says Dr McCullagh.

Professor Fenner has no plans to hang up his hat when he moves his office back to the home shared with his daughter Marilyn. He hopes to devote more time to his beloved vegetable garden, whose produce is regularly shared with friends.

But he has no ambitions to fight against the inevitable. After seeing his good friend Nugget Coombs debilitated and lingering on for many months after a stroke, Professor Fenner wrote an advanced care directive which he carries in his wallet.

“It says ‘if I am found unconscious on the road, don’t do anything to revive me’,” he says. “I don’t want to live for a long time. I want a quick death.”

Whenever and however his last moment comes, one thing is certain. Frank Fenner’s memory will be writ large in the history of Australian science and medicine.

(copyright Melissa Sweet, 2007)

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Update: Have just spotted this piece in Crikey bulletin, Vale Frank Fenner, the greatest public health achiever of all time, by Stephen Luntz, author of Forensics, Fossils and Fruitbats: A Fieldguide to Australian Scientists.

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